St. Joseph School is located in Cottleville, Missouri, in the Archdiocese of St. Louis.

• From I-70 take exit Mid Rivers Road. Travel south to Hwy. N. Turn right on Hwy. N. Drive one mile to Motherhead Road. St. Joseph Parish Church is at the intersection of Highway N and Motherhead. The School is the last building on the campus at the corner of Guttermuth Road and Motherhead.
• From 94 take Mid Rivers Mall Road to Hwy. N. Turn left on Highway N. Drive one mile to Motherhead Road.